|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, our findings suggest that eNOS G894T and T-786C SNPs were both significantly correlated with hypertension</span>.
|
28287883 |
2017 |
|
rs891511
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci.
|
27618448 |
2016 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of endothelial nitric oxide synthase (eNOS) gene G894T polymorphism with hypertension risk and complications.
|
27557897 |
2016 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study evidenced that rs1799983 NOS3 polymorphism could be associated with hypertension and DBP among Southern Europeans, being this association influenced by dietary fat (SFA and MUFA) and body mass index.
|
26994605 |
2017 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Further studies are needed to reveal the usefulness of G894T polymorphism in hyper</span>tension risk assessment in obese.
|
26579574 |
2015 |
|
rs1808593
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The findings of this study indicated that the rs4496877, rs1808593 and rs3918186 polymorphisms of NOS3 contribute to the genetic susceptibility of HT and that rs3918186 was associated with SBP in the Chinese population.
|
26391643 |
2015 |
|
rs3918186
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The findings of this study indicated that the rs4496877, rs1808593 and rs3918186 polymorphisms of NOS3 contribute to the genetic susceptibility of HT and that rs3918186 was associated with SBP in the Chinese population.
|
26391643 |
2015 |
|
rs368332097
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Each analysis consistently revealed the 46A allele of ADRB2 46G/A SNP and 4a allele of NOS3 4b/4a SNP to be associated with risk of hypertension.
|
25159081 |
2015 |
|
rs3918226
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We recently identified rs3918226 as a hypertension susceptibility locus (-665 C>T), TT homozygosity being associated with higher hypertension risk.
|
25102225 |
2015 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, GG phenotype of Glu298Asp polymorphism neither decreased the ESRD risk (OR = 0.77, 95% CI 0.55-1.08, P = 0.13) nor affected the hypertension risk (OR = 1.04, 95% CI 0.66-1.66, P = 0.86).
|
24995932 |
2014 |
|
rs7830
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, no study has tested the hypothesis that NOS3 tagSNPs rs3918226, rs3918188, rs743506 and rs7830 affect nitrite levels and are associated with hypertension in childhood obesity.
|
24943287 |
2015 |
|
rs3918188
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no study has tested the hypothesis that NOS3 tagSNPs rs3918226, rs3918188, rs743506 and rs7830 affect nitrite levels and are associated with hypertension in childhood obesity.
|
24943287 |
2015 |
|
rs743506
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no study has tested the hypothesis that NOS3 tagSNPs rs3918226, rs3918188, rs743506 and rs7830 affect nitrite levels and are associated with hypertension in childhood obesity.
|
24943287 |
2015 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The relationship between the G894T polymorphism and hypertension in Han Chinese may be attributed to the difference in geographic background of subjects.
|
24846690 |
2015 |
|
rs3918226
|
|
|
0.040 |
GeneticVariation |
BEFREE |
For hypertension associations were seen for additional SNPs including NOS3 SNP rs3918226, previously associated with hypertension in genome-wide association study (GWAS) data.
|
24713495 |
2014 |
|
rs3918226
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In conclusion, rs3918226 in the eNOS promoter tags a hypertension susceptibility locus, TT homozygosity being associated with lesser transcription and higher risk of hypertension.
|
24019403 |
2013 |
|
rs2070744
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The C allele at rs2070744 of the NOS3 gene was shown to be significantly associated with hypertension (P=0.0443; OR=1.636).
|
23122309 |
2012 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Regarding the eNOS E298D polymorphism, the frequency of the mutant D allele carriage was only observed to be higher among cases with hypertension associated with diabetes and obesity, in comparison with controls, yet not reaching statistical significance (41.2% vs. 34%, p > 0.05).
|
23042814 |
2013 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The genotypic distribution of the Met235Thr (AGT) and Glu298Asp (NOS3) polymorphisms demonstrated that both are independent risk factors of hypertension (p=0.02 and p=0.008, respectively).
|
22791701 |
2013 |
|
rs891512
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of the intronic polymorphism rs891512 (G24943A) of the endothelial nitric oxide synthase gene with hypertension in Chilean type 2 diabetes patients.
|
22425436 |
2012 |
|
rs3918226
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We identified a new hypertension susceptibility locus (rs3918226) in the promoter region of the endothelial NO synthase gene (odds ratio: 1.54 [95% CI: 1.37-1.73]; combined P=2.58 · 10(-13)).
|
22184326 |
2012 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To examine the relationship of three eNOS gene polymorphisms, T-786C (rs2070744), G894T (rs1799983), and G10T (rs7830), with hypertension</span> in the Han population in southwestern China, we carried out a study of the genotypes of three SNPs in 510 hypertensive and 510 normotensive subjects from the Yunnan Province by using PCR-RFLP and sequencing.
|
21968727 |
2011 |
|
rs2070744
|
|
|
0.040 |
GeneticVariation |
BEFREE |
To examine the relationship of three eNOS gene polymorphisms, T-786C (rs2070744), G894T (rs1799983), and G10T (rs7830), with hypertension in the Han population in southwestern China, we carried out a study of the genotypes of three SNPs in 510 hypertensive and 510 normotensive subjects from the Yunnan Province by using PCR-RFLP and sequencing.
|
21968727 |
2011 |
|
rs7830
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To examine the relationship of three eNOS gene polymorphisms, T-786C (rs2070744), G894T (rs1799983), and G10T (rs7830), with hypertension in the Han population in southwestern China, we carried out a study of the genotypes of three SNPs in 510 hypertensive and 510 normotensive subjects from the Yunnan Province by using PCR-RFLP and sequencing.
|
21968727 |
2011 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We, via a comprehensive meta-analysis, ascertained the role of eNOS G894T and 4b/a polymorphisms on hypertension in Asians, and T-786C polymorphism in Whites.
|
21912683 |
2011 |